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where it transduces signals from the PI3K pathway through dual phosphorylation at T309 by PDK1 and S474 by mTORC2 to adopt an active conformation that phosphorylates >100 substrates—key among them GSK3β
promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes
which is then methylated to melatonin by S-adenosylmethionine catalyzed by acetyl-serotonin O-methyltransferase
Host Mouse Antigen Mouse CD3 Synonyms T-cell surface glycoprotein CD3 zeta chain
TPH-1 Recombinant Rabbit mAb (S-2287-143) Protease Series where it transduces signals fromProduct Specification Host Rabbit Antigen TPH 1 Synonyms Tryptophan 5 hydroxylase 1; Tryptophan 5 monooxygenase 1; TPH; TPRH; TRPH; TPH1 Immunogen Synthetic Peptide Accession P17752 Clone Number S 2287 143 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Predicted Reactivity Rb Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03%
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